Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury
Stewart I, Jacob J, Porter JC, Liu B, Tatler AL, Gomez N, Pugh MR, John AE, Allen RJ, Blaikley JF, Chaudhuri N, Denneny E, Fabbri L, George PM, Guillen-Guio B, Gooptu B, Hall IP, Ho LP, Jarrold I, Johnson S, Jones MG, Khan F, Mehta P, Mitchell J, Molyneaux PL, Pearl JE, Piper Hanley K, Platé M, Quinn V, Rivera-Ortega P, Saunders LC, Smith DJF, Spears M, Spencer LG, Stanel SC, Thompson AAR, Walsh S, Wild JM, Wootton DG, Docherty AB, Gleeson F, Greenhalf W, Harrison EM, Lone N, Quint J, Maslova A, Pohl M, Stephens A, Young S, Singapuri A, Shikotra A, Sereno M, Saunders RM, Richardson M, Raman B, Poinasamy K, McAuley HJC, Marks M, Leavy OC, Houchen-Wolloff L, Horsley A, Harris VC, Greening N, Evans RA, Elneima O, Chalmers JD, Brightling CE, Chambers RC, Wain LV, Jenkins RG and
Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury
Stewart I, Jacob J, Porter JC, Liu B, Tatler AL, Gomez N, Pugh MR, John AE, Allen RJ, Blaikley JF, Chaudhuri N, Denneny E, Fabbri L, George PM, Guillen-Guio B, Gooptu B, Hall IP, Ho LP, Jarrold I, Johnson S, Jones MG, Khan F, Mehta P, Mitchell J, Molyneaux PL, Pearl JE, Piper Hanley K, Platé M, Quinn V, Rivera-Ortega P, Saunders LC, Smith DJF, Spears M, Spencer LG, Stanel SC, Thompson AAR, Walsh S, Wild JM, Wootton DG, Docherty AB, Gleeson F, Greenhalf W, Harrison EM, Lone N, Quint J, Maslova A, Pohl M, Stephens A, Young S, Singapuri A, Shikotra A, Sereno M, Saunders RM, Richardson M, Raman B, Poinasamy K, McAuley HJC, Marks M, Leavy OC, Houchen-Wolloff L, Horsley A, Harris VC, Greening N, Evans RA, Elneima O, Chalmers JD, Brightling CE, Chambers RC, Wain LV, Jenkins RG and
Long term respiratory symptoms are reported following recovery of acute COVID-19 infection and residual lung abnormalities (RLA) on follow-up thoracic computed tomography (CT) after COVID-19 hospitalisation have been observed. It is unknown whether RLA are associated with epithelial lung injury.
Incidence of diabetes mellitus following hospitalisation for COVID-19 in the United Kingdom: A prospective observational study
Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F, Yates T, Davies MJ, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Evans RA, Greening NJ, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Leavy OC, Lone NI, Marks M, McAuley HJC, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders R, Sereno M, Shikotra A, Singapuri A, Wain LV, Khunti K and
Incidence of diabetes mellitus following hospitalisation for COVID-19 in the United Kingdom: A prospective observational study
Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F, Yates T, Davies MJ, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Evans RA, Greening NJ, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Leavy OC, Lone NI, Marks M, McAuley HJC, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders R, Sereno M, Shikotra A, Singapuri A, Wain LV, Khunti K and
People hospitalised for coronavirus disease 2019 (COVID-19) have elevated incidence of diabetes. However, it is unclear whether this is due to shared risk factors, confounding or stress hyperglycaemia in response to acute illness.
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho LP, Marks M, Poinasamy K, Raman B, Shikotra A, Singapuri A, Sereno M, Harris VC, Houchen-Wolloff L, Saunders RM, Greening NJ, Richardson M, Quint JK, Briggs A, Docherty AB, Kerr S, Harrison EM, Lone NI, Thorpe M, Heaney LG, Lewis KE, Aul R, Beirne P, Bolton CE, Brown JS, Choudhury G, Bakerly ND, Easom N, Echevarria C, Fuld J, Hart N, Hurst JR, Jones MG, Parekh D, Pfeffer P, Rahman NM, Rowland-Jones SL, Thompson AR, Jolley C, Shah AM, Wootton DG, Chalder T, Davies MJ, De Soyza A, Geddes JR, Greenhalf W, Heller S, Howard LS, Jacob J, Jenkins RG, Lord JM, Man WD, McCann GP, Neubauer S, Openshaw PJ, Porter JC, Rowland MJ, Scott JT, Semple MG, Singh SJ, Thomas DC, Toshner M, Smith N, Sheikh A, Brightling CE, Wain LV, Evans RA and
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho LP, Marks M, Poinasamy K, Raman B, Shikotra A, Singapuri A, Sereno M, Harris VC, Houchen-Wolloff L, Saunders RM, Greening NJ, Richardson M, Quint JK, Briggs A, Docherty AB, Kerr S, Harrison EM, Lone NI, Thorpe M, Heaney LG, Lewis KE, Aul R, Beirne P, Bolton CE, Brown JS, Choudhury G, Bakerly ND, Easom N, Echevarria C, Fuld J, Hart N, Hurst JR, Jones MG, Parekh D, Pfeffer P, Rahman NM, Rowland-Jones SL, Thompson AR, Jolley C, Shah AM, Wootton DG, Chalder T, Davies MJ, De Soyza A, Geddes JR, Greenhalf W, Heller S, Howard LS, Jacob J, Jenkins RG, Lord JM, Man WD, McCann GP, Neubauer S, Openshaw PJ, Porter JC, Rowland MJ, Scott JT, Semple MG, Singh SJ, Thomas DC, Toshner M, Smith N, Sheikh A, Brightling CE, Wain LV, Evans RA and
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF and
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF and
Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other scenarios. We aimed to investigate the prevalence and nature of sleep disturbance after discharge following hospital admission for COVID-19 and to assess whether this was associated with dyspnoea.
ADCOMS sensitivity versus baseline diagnosis and progression phenotypes
Evenden D, Prosser A, Michopoulou S, Kipps C and
ADCOMS sensitivity versus baseline diagnosis and progression phenotypes
Evenden D, Prosser A, Michopoulou S, Kipps C and
The Alzheimer's Disease COMposite Score (ADCOMS) is more sensitive in clinical trials than conventional measures when assessing pre-dementia. This study compares ADCOMS trajectories using clustered progression characteristics to better understand different patterns of decline.
Hybrid simulation modelling for dementia care services planning
Evenden D, Evenden DC, Brailsford SC, Kipps CM, Roderick PJ and Walsh B
Hybrid simulation modelling for dementia care services planning
Evenden D, Evenden DC, Brailsford SC, Kipps CM, Roderick PJ and Walsh B
Dementia is an increasing problem in today’s ageing society, and meeting future demand for care is a major concern for policy-makers and planners. This paper presents a novel hybrid simulation model that simultaneously takes population-level and patient-level perspectives to calculate the numbers of patients at different stages of disease severity over time, and their associated care costs. System Dynamics is used at population level to capture ageing, dementia onset, and all-cause mortality, whereas disease progression is modelled at individual patient level using Agent-Based methods. This enables the model to account for variability between patients in the rate of cognitive decline, dementia-related mortality and response to treatment interventions. Using epidemiological data from the medical literature, disease progression is modelled via a longitudinal clustering method to identify progression type, followed by mixed-effects regression to reflect each individual’s rate of cognitive decline. Results are presented for population data from the south of England, and show that the currently available interventions have only modest effects at population level.
