Dr Sofia Michopoulou
Medical Physics Expert

Diagnosis and prognosis

Portrait image of Sofia Michopolou

Sofia is a medical physics expert (MPE) for nuclear medicine and an NIHR clinical lecturer. She supports the nuclear medicine, SPECT/CT and PET/CT services at UHS and leads the introduction of new diagnostic and therapeutic techniques.

Sofia teaches medical imaging at BSc and MSc level at the University of Southampton and delivers part of the Fellows of Royal College of Radiology (FRCR) physics module.

Sofia’s research focuses on developing imaging biomarkers and evaluating the role of imaging and inflammation on dementia diagnosis and prognosis using artificial intelligence methods. She also works on translating research outcomes into clinical application at Southampton General Hospital.

recent publications:

Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review
Borchert RJ, Azevedo T, Badhwar A, Bernal J, Betts M, Bruffaerts R, Burkhart MC, Dewachter I, Gellersen HM, Low A, Lourida I, Machado L, Madan CR, Malpetti M, Mejia J, Michopoulou S, Muñoz-Neira C, Pepys J, Peres M, Phillips V, Ramanan S, Tamburin S, Tantiangco HM, Thakur L, Tomassini A, Vipin A, Tang E, Newby D, , Ranson JM, Llewellyn DJ, Veldsman M and Rittman T
Artificial intelligence (AI) and neuroimaging offer new opportunities for diagnosis and prognosis of dementia.
Brain PET and SPECT imaging and quantification: a survey of the current status in the UK
Michopoulou SK, Dickson JC, Gardner GG, Gee TR, Fenwick AJ, Melhuish T, Monaghan CA, O'Brien N, Prosser AMJ, Scott CJ, Staff RT and Taylor J
With disease-modifying therapies in development for neurological disorders, quantitative brain imaging techniques become increasingly relevant for objective early diagnosis and assessment of response to treatment. The aim of this study was to evaluate the use of Brain SPECT and PET scans in the UK and explore drivers and barriers to using quantitative analysis through an online survey.
Biomarkers of Inflammation Increase with Tau and Neurodegeneration but not with Amyloid-β in a Heterogenous Clinical Cohort
Michopoulou S, Prosser A, Kipps C, Dickson J, Guy M and Teeling J
Neuroinflammation is an integral part of Alzheimer's disease (AD) pathology. Inflammatory mediators can exacerbate the production of amyloid-β (Aβ), the propagation of tau pathology and neuronal loss.
Perfusion Imaging and Inflammation Biomarkers Provide Complementary Information in Alzheimer's Disease
Michopoulou S, Prosser A, Dickson J, Guy M, Teeling JL and Kipps C
Single photon emission tomography (SPECT) can detect early changes in brain perfusion to support the diagnosis of dementia. Inflammation is a driver for dementia progression and measures of inflammation may further support dementia diagnosis.
ADCOMS sensitivity versus baseline diagnosis and progression phenotypes
Evenden D, Prosser A, Michopoulou S, Kipps C and
The Alzheimer's Disease COMposite Score (ADCOMS) is more sensitive in clinical trials than conventional measures when assessing pre-dementia. This study compares ADCOMS trajectories using clustered progression characteristics to better understand different patterns of decline.

research projects:

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