The use of e-health platforms is expanding rapidly, but their promise of more efficient and effective healthcare will not be realised if the user experience is poor and people fail to use them, or if their success is measured through outcomes which do not reflect service-user value. A comprehensive literature review was undertaken to identify the range of digital tools in use across neurological conditions, their underling functionality and salient clinical outcomes. The review highlighted important factors including user-friendliness, interactivity, design principles, and information provision across range of long-term conditions.